Ph.D. Biochemistry, University Buffalo at Roswell Park Cancer Institute. [doctoral thesis]

B.S. Microbiology, Cornell University.

Competitive Intelligence Professional, Academy of Competitive Intelligence.

Medical Committee USA Climbing 2020-2022 Chair.

OPINION: "NO MAGIC PRP"


Jane Y. Chin, Ph.D. et al (Unpublished, 2023)


Commercial PRP systems in the United States lack standard interpretation normalized to volume of donor blood drawn. Manufacturers’ PRP kit assay-data submitted to the FDA are not published for peer-review, leaving healthcare providers and researchers to rely on marketing claims or independent evaluations by academic researchers. None of the 7 current PRP classification approaches have been adopted in clinical practice, and standard dose-response studies for PRP orthobiologic applications are lacking. 


Regardless of data origin or centrifugation steps (number of "spins"), normalizing platelet yield by total blood volume required shows platelet numbers range from 73 to 180 (average 125.5 +/- 53.1) million per milliliter of drawn blood. Heterogeneity of platelet yield occurs in the same commercial systems conducted by the same laboratories, further negating the clinical relevance of commercial "X concentration" claims. Recent knee osteoarthritis data suggest PRP impaired responders showed higher absolute platelet counts compared to PRP responders, with twice the concentration of pro-angiogenic growth factors VEGF and EGF without significantly higher TGF-b1 in their PRP. 


Given that platelet concentrations of commercial PRP kits come from healthy donors and not patients, a critical aspect of future PRP data quality control should include analyses of normalized platelet counts in “clinical responders” versus “clinical sub-optimal-” or “clinical non-responders” when evaluating any commercial PRP devices.

CART-23-0095_PRP PAPER.pdf

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